More than the years, many in vitro and in vivo studies have shown the antineoplastic effects of cannabinoids (CBDs), with reports advocating for investigations of mixture therapy approaches that could much better leverage these effects in clinical translation. This study explores the prospective of mixture approaches employing CBDs with radiotherapy (RT) or intelligent biomaterials toward enhancing therapeutic efficacy for the duration of remedy of pancreatic and lung cancers. In in vitro studies, clonogenic assay final results showed higher productive tumor cell killing, when combining CBDs and RT. Meanwhile, in vivo study final results revealed key improve in survival when employing intelligent biomaterials for sustained delivery of CBDs to tumor cells. The significance of these findings, considerations for additional investigation, and viable roadmap to clinical translation are discussed.
Copyright © 2018 Elsevier B.V. All rights reserved.
PMID: 29740535 PMCID: PMC5928848 DOI: 10.3389/fonc.2018.00114
Yasmin-Karim S1,two,three, Moreau Mtwo,three,four, Mueller R1,two,five, Sinha N1,two, Dabney Rsix, Herman Asix, Ngwa W1,two,three,four.