Actor Seth Rogan with his wife, actress Lauren Miller, at the 69th Annual Golden Globes Awards. Supply: jdeeringdavis, Fickr

Whilst he might be recognized for his really like and appreciation of cannabis, Seth Rogen is utilizing his platform to attempt and give millions of dollars back to one thing else totally.

The Pineapple Express and Knocked Up star has been functioning for almost eight years now to combat Alzheimer’s, like hosting a wide variety of events to raise cash for the trigger by means of his organization, “Hilarity for Charity.” Rogen, who began a cannabis business earlier this year, testified to congress in 2014 that “First I must answer the query I assume a lot of of you are asking, yes I’m conscious this has nothing at all to do with the legalization of marijuana. In truth, if you can think it, this issues one thing that I come across even extra critical.”

His most current a single was an adult-only carnival that was themed about marijuana. Comedians and performers lined up the occasion which saw the cash go toward treating and fighting the illness.

What is Hilarity for Charity?

In 2012, Seth Rogen and his wife Lauren Miller Rogen have been faced with understanding that Lauren’s mother had been diagnosed with early-onset Alzheimer’s. 

An incurable and terminal illness, Alzheimer’s causes your brain cells to commence to die away, causing memory loss and sooner or later the deterioration of cognitive function. The most frequent trigger of dementia, there are up to 3 million instances in America every year.

Faced with this predicament, Rogen and his wife set out to do what they could to make a distinction. Hence Hilarity for Charity was born.

In 2012, the very first of what would grow to be almost a dozen fundraising events to raise cash was hosted by Rogen and raised $300,000 though featuring Bruno Mars, Aziz Ansari, and Judd Apatow. 

By means of the years, guests such as Mindy Kaling, The Backstreet Boys, Natasha Leggero, Ilana Glazer and extra would join the festivities to aid raise millions.

Throughout this time, Rogen and his group set up a series of applications to aid help Alzheimer’s study and help, like more than $three million dollars for help grants for these living with the illness, young adult education applications and funding for extra study.

Rogen’s most higher profile occasion to date came in the kind of a Netflix specific, which gave millions of folks about the globe the likelihood to see specifically what Rogen and his group are all about. The 2018 specific featured Tiffany Haddish, John Mulaney, Jeff Goldblum, John Kroll, and extra performing.

This year was the very first time a marijuana-themed occasion was held, marking Rogen’s two loves coming with each other.

With Tony Hawk, Josh Gad, Ilana Glazer, and even extra stars joining, the occasion marked the very first carnival hosted by the group in an work to attempt and have entertaining in assistance of a really serious trigger.

“I believe simply because I felt alone, it was critical to generate one thing exactly where young folks could really feel a aspect of this illness and really feel like they could have a hand in fighting against it,” Lauren Rogen told Individuals. “That notion just led to, combined with the truth that Seth is a comedian and I’m type of funny, it is just what came naturally to us.”

All in all, Hilarity for Charity has raised more than $7 million dollars to combat Alzheimer’s because it started.

Alzheimer’s and Cannabis

Whilst only the most current occasion was cannabis themed, Seth Rogen’s really like of cannabis might truly have a powerful connection with his fight against Alzheimer’s.

Like most places regarding cannabis, there is small study on if marijuana aids fight the illness, but what we do know is good.

In 2014, a preclinical trial study was published by the Journal of Alzheimer’s Illness stating that little amounts of tetrahydrocannabinol (THC), the psychoactive ingredient in cannabis that gets you “high,” can “slow the production of beta-amyloid proteins, believed to be a hallmark characteristic and crucial contributor to the progression of Alzheimer’s.”

By stopping the formation and slowing down the occurrence of toxic amyloid plaques, which are compounds that trigger the illness, a single of the author’s of the study above mentioned that THC could be a substantial aid in fighting the illness down the line.

“It’s critical to maintain in thoughts that just simply because a drug might be helpful does not imply it can be safely utilised by everyone,” Neel Nabar mentioned. “However, these findings might lead to the improvement of associated compounds that are secure, legal, and beneficial in the therapy of Alzheimer’s illness.”

The study went on to present how inflammation in the brain from the illness could be helped by the presence of THC.

One particular of the detrimental effects from the illness is inflammation which causes nerve cells to die in the brain, furthering the effects of the illness. 

Antonio Currais, a postdoctoral researcher and author on the paper noted that:

“Inflammation inside the brain is a important element of the harm related with Alzheimer’s illness, but it has constantly been assumed that this response was coming from immune-like cells in the brain, not the nerve cells themselves. When we have been capable to recognize the molecular basis of the inflammatory response to amyloid beta, it became clear that THC-like compounds that the nerve cells make themselves might be involved in guarding the cells from dying.”

Needless to say, extra study will have to have to be carried out just before any conclusions can be produced, but that does not make the findings any much less fascinating going forward.

Also getting looked into is how cannabis can combat the effects of the illness with some medical doctors saying that cannabis might be a useful tool in treating the aggression that a lot of Alzheimer’s individuals achieve.

Having said that, when it comes to cognitive function, marijuana will most likely not be stopping Alzheimer’s from current, in truth, it could make items worse.

Dr. Nathan Hermann, who final year presented a study regarding synthetic cannabinoids and aggression in Alzheimer’s individuals mentioned, “There is no cause to suspect that cannabinoids would increase cognitive skills in Alzheimer’s illness. In truth, there is very good cause to be concerned that cannabinoids could make cognitive function worse, either by direct effects or by causing excessive sedation.”